Teenage Acne in Adolescent Girls

Teenage Acne in Adolescent Girls: Acne vulgaris is the single most common skin disease affecting an estimated 85% of teenage boys and 80% of teenage girls [1]. Acne vulgaris is an extremely common disorder that affects virtually all individuals at least once during life. The incidence of acne peaks at teenage in men and women [2].

Polycystic ovary syndrome (PCOS) is the most frequent cause of menstrual disorder in teenage girls. PCOS has effects on ovalutory function, hirsutism, acne, hormonal pattern and body weight in adolescent girls.

Metformin tablet given at the dose of 1700 mg/day for a period of 6 months has been shown to have positive effect on the menstrual cycle and drug can be administered to young women to improve ovulation, hyper androgenic symptoms such as hirsutism, acne and weight gain [3].

Hyperandrogenism must be considered in any girl with premature pubarche, unusual acne, hirsutism or androgenic alopecia. An association with menstrual irregularity or obesity should raise the index of suspicion. The most common causes of hyperandrogenism presenting in a teenage girl are functional ovarian hyperandrogenism. One manifestation of which is polycystic ovary syndrome and functional adrenal hyperandrogenism which usually seems due to an exaggeration of adrenarche.

The plasma free testosterone is a more sensitive indicator of hyperandrogenism than is the total testosterone concentration. The pattern of response of plasma free testosterone, DEAS and cortisol to dex suppression testing can be diagnostic of the source of androgen excess.

Treatment including oral contraceptives, low dose glucocorticoids and antiandrogens should be chosen according to patient symptoms and source of androgens and should be considered with traditional therapy for dermatological disorders [4].

Direct relation between acne and hirsuties in teenagers is reported. Acne and body hair are both cutaneous responses to androgenic stimulation. They are normal events in adolescent girls [5].

Women are especially affected throughout their reproductive years either as a continuation of teenage acne or adult onset acne [6]. Women with highly irregular menstrual cycle were diagnosed for history of severe teenage acne [7] Teenage Acne in Adolescent Girls. [1] Drugs, 2003, 63(15) : 1579-1596 [2] Br. J. Dermatol., 1979, 1: 1109-1110 [3] Human Reproduction, 2005, 21(9) :2252-2256 [4] Endocrinology Metab. Clin. North Am., 1993, 22(3) : 507-532 [5] Best Practice & Research Clinical Obstetrics & Gynecology, 17(1) : 131-148. [6] Skin Pharmacol Appl Skin Physiol., 1999, 12 : 139-143 [7] The Journal of the American Medical Association, 2001, 286(19) : 2421-2426

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